Thursday, April 17, 2008

Cell Article on Open Drug Discovery

Seema Singh wrote a review "India Takes an Open Source Approach to Drug Discovery" which just appeared in Cell: Volume 133, Issue 2, 18 April 2008, Pages 201-203. (The doi doesn't work yet but try this link in the meantime). You'll need a subscription to view it, an increasingly familiar irony of much of the Open Science discussion these days.

UsefulChem and our collaborators got a nice mention:
A related initiative is UsefulChem (http://usefulchem.wikispaces.com/), set up by Drexel University chemist Jean-Claude Bradley. Bradley has pioneered Open Notebook Science in which lab notebooks and raw research data are posted on the web for anyone to see and respond to (http://usefulchem.wikispaces.com/All+Reactions). As for success, Bradley says, “Probably the best example of a positive outcome from UsefulChem is finding two compounds that are somewhat active against malaria [in vitro],” blocking the activity of falcipain-2, a Plasmodium falciparum cysteine protease. “This demonstrates that a team of researchers can work together in the open—Rajarshi Guha from Indiana University did the docking calculations, my group at Drexel did the syntheses and Phil Rosenthal's group at UCSF did the testing.”

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2 Comments:

At 10:06 AM, Blogger Srinivas said...

My paper on Open Source Drug Discovery can be downloaded from
SSRN
http://papers.ssrn.com/sol3/cf_dev/AbsByAuth.cfm?per_id=290086

 
At 8:07 AM, Anonymous Anonymous said...

I recently checked out this system- XTRactor – it provides 100% manually annotated data for all drug discovery related areas. A techinically-qualified team in INDIA manually curates all the abstracts from Pubmed as and when they are published. And more so it acts as an alert service to track your areas of interest and present them to your inbox regularly. Check it out for free at : www.xtractor.in
What more no need to do topic tracking for your research needs the data gets added to your profile at ease, just you need to provide your Keyword’s of choice.

It also has collaboration and community building exercise, which makes it far more attractive.

 

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