Wednesday, February 15, 2006

Praziquantel synthesis request

There is a request from Mat Todd in TheSynapticLeap for contributions to the synthesis of Praziquantel, an anti-schistosomiasis medicine. Thanks to Marc for the link.

Update: ChemRefer just suggested this thesis as a previous attempt at a more efficient synthesis of praziquantel:

http://etd.fcla.edu/SF/SFE0000266/Thesis.pdf

6 Comments:

At 7:32 AM, Blogger ChemRefer said...

This is the URL of a previous attempt at a more efficient synthesis of praziquantel:

http://etd.fcla.edu/SF/SFE0000266/Thesis.pdf

 
At 9:28 AM, Blogger Science Writer David Bradley said...

This comment has been removed by a blog administrator.

 
At 9:29 AM, Blogger Science Writer David Bradley said...

I just wrote a short news story about the separation of the enantiomers of this anthelminthic compound and its crystal structure in my spectroscopynow news pages.

Praziquantel structure

 
At 12:29 PM, Anonymous Anonymous said...

No real expertise here, but is there anything in the patent literature, eg, http://www.delphion.com/details?pn=CN01683346A_ ?

 
At 1:45 PM, Blogger Jean-Claude Bradley said...

I suspect that they are looking to avoid patents.

 
At 5:04 PM, Anonymous Anonymous said...

Why would you "avoid" patents when they are an outstanding (and often overlooked) source of technical information? Assuming (quite possibly incorrectly) that this process (which is the subject of only a pending patent and only in China) might really be useful to this quest - why in the world would you avoid it? Under what conditions might you access this technology? Might simply talking with the patent applicants yield new information - even that working with them is desirable (and may accelerate delivery of this critically needed compound)? Humble suggestion: keep all eyes on the prize, be innovative, don't cast anything aside because it doesn't fit with preconceived notions...

 

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