Wednesday, December 21, 2005

malaria solid support DKP synthesis

Here is a more explicit general scheme (based on this) showing the general synthesis of the diketopiperazines (DKP) of our malaria project requiring 2 BOC-protected amino acids and one aldehyde. If any alcohols, thiols or amines are present they need to be protected (e.g. benzyl, FMOC, etc.) and deprotected in the last step.

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